Gastric carcinoma, diffuse type (mucinous)
Gastric adenocarcinoma is a malignant epithelial tumor, originating from glandular epithelium of the gastric mucosa. According to Lauren classification, gastric adenocarcinoma may be: intestinal type, diffuse type and mixed type.
Gastric adenocarcinoma, diffuse (infiltrative) type. Tumor cells are discohesive and secrete mucus which is delivered in the interstitium producing large pools of mucus/colloid (optically "empty" spaces) - mucinous (colloid) adenocarcinoma, poorly differentiated (Lauren classification). If the mucus remains inside the tumor cell, it pushes the nucleus against the cell membrane - "signet-ring cell". (H&E, ob. x10)
Gastric carcinoma, diffuse type (mucinous) - detail
Gastric adenocarcinoma, diffuse type. (H&E, ob. X20)
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