Gastric carcinoma, intestinal type

Gastric adenocarcinoma is a malignant epithelial tumor, originating from glandular epithelium of the gastric mucosa. According to Lauren classification, gastric adenocarcinoma may be: intestinal type, diffuse type and mixed type.

Gastric carcinoma intestinal type

Gastric adenocarcinoma, intestinal type. Tumor cells describe irregular tubular structures, with stratification, multiple lumens surrounded by a reduced stroma ("back to back" aspect). The tumor invades the gastric wall, infiltrating the muscularis mucosae, the submucosa and thence the muscularis propria. Often it associates intestinal metaplasia in adjacent mucosa. Depending on glandular architecture, cellular pleomorphism and mucosecretion, adenocarcinoma may present 3 degrees of differentiation : well (photo), moderate and poorly differentiate. (H&E, ob. x10)



Gastric carcinoma intestinal type

Gastric adenocarcinoma, intestinal type, infiltrating muscularis propria. (H&E, ob. x10)



Gastric carcinoma intestinal type - detail

Gastric adenocarcinoma, intestinal type. (H&E, ob. X40)

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Last updated : 01/30/2009