Diffuse lymphocytic non-Hodgkin's lymphoma
Non-Hodgkin's malignant lymphomas comprise a heterogeneous group of malignancies of the immune system (except Hodgkin's lymphoma). The majority (85%) results from a proliferation of B-cells; only 15 % derives from T/NK cells.
Diffuse lymphocytic non-Hodgkin's lymphoma. Lymph node architecture is replaced by tumor proliferated lymphocytes. Lymphoid follicles are absent. Tumor lymphocytes resemble normal lymphocytes (small, monomorphic, round hyperchromatic homogenous nuclei, reduced cytoplasm), but are immature, monoclonal, non-functional. Lymph node capsule is infiltrated by tumor cells. In most of the cases, these tumor cells have a B-cell origin. (H&E, ob. x10)