Osteosarcoma (osteogenic sarcoma)

Osteosarcoma (osteogenic sarcoma)

Osteosarcoma (osteogenic sarcoma) is a malignant tumor whose neoplastic cells present osteoblastic differentiation and form tumor bone. Tumor cells are very pleomorphic (anaplastic), some are giant and present numerous and atypical mitotic figures. These cells produce osteoid describing irregular trabeculae (amorphous, eosinophilic/pink) with or without central calcification (hematoxylinophilic/blue, granular) - tumor bone. Tumor cells are included in the osteoid matrix. Cartilage may be present. Presence of immature blood vessels (sarcomatous vessels lacking endothelial cells) favors the bloodstream metastasizing. (Hematoxylin-eosin, ob. x10)



Osteosarcoma (osteogenic sarcoma)

Osteosarcoma (osteogenic sarcoma) (H&E, ob. x10)

Last updated : 01/30/2009